Clomid for bodybuilding (Clomiphene Citrate) is an anti-estrogen, binding is in effect on the hypothalamus and the gonads. The drug causes the pituitary gland to secrete needed to stimulate ovulation (the release of an egg from the ovary) and thereby increasing the chances of a woman getting pregnant. Clomiphene has also been used to increase the sperm count of male patients with idiopathic oligospermia (insufficient sperm for fertilization of the egg). The FDA first approved clomiphene in USA in 1967.
In addition to the use of drugs in medicine for the treatment of various diseases associated with infertility and problems with conception in women, Clomid is a fairly popular tool in the power sports and used for PCT. We can say that this is one of the main drugs that is required on the course. It is used to start the ARC (axis hypothalamus-pituitary-testes).
Unlike Tamoxifen, Clomid is a drug of the “new generation”. However, due to its selectivity Clomiphene Citrate, is an estrogen antagonist for some tissues, can be a real estrogen for others. But fortunately, this when use of the drug men were not observed.
WHAT IS CLOMID FOR BODYBUILDING – DESCRIPTION OF CLOMIPHENE CITRATE
Clomiphene Citrate – the color of the drug can be white or pale yellow, essentially odorless. The substance is freely soluble in methanol, ethanol. It has low solubility in acetone, water and chloroform. Not soluble in ether. Clomid for bodybuilding is a mixture of two geometric isomers [CIS (zuclomiphene) and TRANS (enclomiphene)] containing between 30 to 50% of the CIS isomer. One tablet of the drug contains 50 mg of active substance, as well as some inactive ingredients: corn starch, lactose, magnesium stearate, pregelatinized corn starch and sucrose.
Thanks to the ability to bind to estrogen receptors in the hypothalamus, Clomiphene Citrate significantly increases the level of GnRH (GnRH), follicle-stimulating hormone (FSH) and luteinizing hormone (LH), thereby resulting in more production of testosterone testicles in men, and estrogen in women. But, according to studies, this effect does not exceed of clomid, but sometimes be lower than the cheaper and more common Tamoxifen. Direct impact on the amount of estrogen Clomid has not. Its mechanism of action is to block their access to the pituitary and consequent increase in follicle-stimulating hormone and luteinizing hormone. The available data suggest that both estrogenic and antiestrogenic properties of Clomiphene may participate in the beginning of ovulation. It was discovered that the two Clomiphene isomers have mixed estrogenic and antiestrogenic effects, which may vary from one species to another. Some evidence suggests that zuclomiphene has greater estrogenic activity than enclomiphene.
Clomiphene Citrate has no apparent progestational, androgenic, or antiandrogenic effects and apparently does not interfere with the function of the pituitary-adrenal or pituitary thyroid. Despite the absence of signs of “portable effect” in some patients after Clomid therapy was noted spontaneous ovulatory menses.
PHARMACOKINETICS CLOMIPHENE CITRATE
Based on early studies with 14C-labeled Clomiphene Citrate, it has been shown that the drug is readily absorbed orally in patients and excreted from the feces. Cumulative excretion in urine and faeces of 14C averaged about 50 % of the oral dose and 37% of an intravenous dose after 5 days. Some studies have shown that the substance was still present in the feces in patients even after 6 weeks after injection. Subsequent single clinical studies in normal volunteers showed that zuclomiphene (CIS) has a longer half-life than enclomiphene (TRANS). Discovered levels zuclomiphene persisted for more than a month. This may indicate stereospecific enterohepatic recycling or sequestering of zuclomiphene. Thus, it is possible that the active substance may remain in the body during early pregnancy in women.
HOW TO TAKE CLOMID FOR BODYBUILDING PCT?
Athletes do not use it during cycles, anabolic steroids on cycle, it is advisable to take aromatase inhibitors. Clomiphene is used after a course of steroids in bodybuilding PCT, helping athletes remained
CLOMID SIDE EFFECTS
Its action may adversely affect vision. This drug has a toxic effect on the liver, but it is less than that of Tamoxifen. Also in athletes who use Clomiphene may experience side effects such as headache, dizziness, insomnia, drowsiness, upset digestive system, nausea and vomiting.
In most cases, all side effects disappear after its use. It should be noted that the use of Clomiphene Citrate increases the risk of occurrences of blood clots. In order to reduce this risk to a minimum, during the application it is necessary to increase the amount of drinking water per day at least 1 liter.